Document Detail

Periodic whole body acceleration: a novel therapy for cardiovascular disease.
MedLine Citation:
PMID:  18357918     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Periodic whole body acceleration in the spinal axis (pGz) applied by a motion platform is a novel treatment modality that induced endothelial nitric oxide release into the circulation of animals, healthy subjects and patients with inflammatory diseases during single treatment sessions in previous studies. We hypothesized that patients with advanced arteriosclerotic diseases who are not candidates for a surgical intervention would clinically benefit from repeated pGz treatments over several weeks through improvement of endothelial function.
PATIENTS AND METHODS: 11 patients, 5 men (37 to 71 y) with stable ischemic heart disease, LVEF < 35%, NYHA stage > II, and 6 patients (51 to 83 y, 1 woman) with intermittent leg claudication, Fontaine stage II, were enrolled after optimization of pharmacological therapy. PGz was applied for 40 min, 5 days/week during 5 weeks. Quality of life (SF-36 questionnaire), exercise performance, and endothelial function were assessed at baseline, during the treatment period, and 4 weeks after discontinuation of pGz.
RESULTS: PGz was well tolerated. In heart failure paitents, pGz therapy improved quality of life, increased 6 min walking distance by a mean +/- SE of 105 +/- 24 m, and improved postischemic skin hyperemia (p < .05 in all instances). In 4 of 6 patients with intermittent claudication, quality of life, treadmill walking distance and post-ischemic skin hyperemia improved with pGz therapy (p < .05). Four weeks after discontinuation of pGz, most therapeutic effects had vanished in both patient groups.
CONCLUSIONS: In patients with severe heart failure and with leg claudication who remain symptomatic despite maximal medical therapy and who were not candidates for surgery, periodic acceleration applied over several weeks improved quality of life and exercise capacity. The clinical benefits appear to be mediated through improved endothelial function.
M Kohler; B R Amann-Vesti; C F Clarenbach; T Brack; G Noll; E W Russi; K E Bloch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  36     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-04-30     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Pulmonary Divison, Dept. of Internal Medicine, University Hospital of Zurich, Switzerland.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology,  rehabilitation*
Coronary Artery Disease / physiopathology,  rehabilitation*
Endothelium, Vascular / physiopathology
Exercise Test
Heart Failure / physiopathology,  therapy
Intermittent Claudication / physiopathology,  therapy
Ischemia / therapy*
Leg / blood supply*
Middle Aged
Nitric Oxide / blood
Physical Therapy Modalities / instrumentation*
Quality of Life
Treatment Outcome
Reg. No./Substance:
10102-43-9/Nitric Oxide

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