| Periodic transfusions for sickle cell anemia and CNS infarction. | |
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MedLine Citation:
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PMID: 517476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrences of CNS infarction often lead to progressive neurologic disability in sickle cell anemia. To prevent such reccurrence, a periodic blood transfusion program was begun in 1969. Currently, 27 patients are on this regimen. Before inclusion in the program, 12 patients had had one to nine CNS recurrences each. Since the program was started, two patients have had transient CNS ischemia. There were no other recurrences and none of the patients have shown progression of neurologic abnormalities. In addition, there was a striking decrease in bacterial infection and pain. We conclude that periodic transfusions are effective in preventing recurrent CNS infarction in sickle cell anemia. The benefits must be weighed against the potentially serious problem of iron overload, as evidenced by moderately elevated serum ferritin values. |
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Authors:
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S Sarnaik; D Soorya; J Kim; Y Ravindranath; J Lusher |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 133 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1979 Dec |
Date Detail:
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Created Date: 1980-02-15 Completed Date: 1980-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1254-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Sickle Cell / blood, complications, therapy* Blood Transfusion* Cerebral Infarction / etiology, prevention & control* Child Child, Preschool Female Ferritins / blood Humans Male Recurrence |
| Chemical | |
Reg. No./Substance:
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9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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