| Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding. | |
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MedLine Citation:
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PMID: 12527997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used single photon emission computed tomography (SPECT) to study striatal [(123)I]beta-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [(123)I]beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients. |
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Authors:
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Svenja Happe; Walter Pirker; Gerhard Klösch; Cornelia Sauter; Josef Zeitlhofer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurology Volume: 250 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-15 Completed Date: 2003-04-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 83-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurology, University of Vienna, Austria. shappe@gwdg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cocaine / analogs & derivatives*, diagnostic use Corpus Striatum / metabolism*, pathology, radionuclide imaging Dopamine Plasma Membrane Transport Proteins Female Humans Male Membrane Glycoproteins* Membrane Transport Proteins / metabolism* Middle Aged Nerve Tissue Proteins* Nocturnal Myoclonus Syndrome / metabolism, physiopathology* Parkinson Disease / metabolism, physiopathology*, radionuclide imaging Polysomnography Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Radiopharmaceuticals; 133647-95-7/RTI 55; 50-36-2/Cocaine |
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