Document Detail

Periodic heart rate decelerations in premature infants.
MedLine Citation:
PMID:  20407086     Owner:  NLM     Status:  MEDLINE    
The pacemaking system of the heart is complex; a healthy heart constantly integrates and responds to extracardiac signals, resulting in highly complex heart rate patterns with a great deal of variability. In the laboratory and in some pathological or age-related states, however, dynamics can show reduced complexity that is more readily described and modeled. Reduced heart rate complexity has both clinical and dynamical significance - it may provide warning of impending illness or clues about the dynamics of the heart's pacemaking system. In this paper, we describe simple and interesting heart rate dynamics that we have observed in premature human infants - reversible transitions to large-amplitude periodic oscillations - and we show that the appearance and disappearance of these periodic oscillations can be described by a simple mathematical model, a Hopf bifurcation.
Abigail A Flower; J Randall Moorman; Douglas E Lake; John B Delos
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  235     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-04-28     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
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MeSH Terms
Biological Clocks / physiology
Heart Conduction System / physiology*
Heart Rate / physiology*
Infant, Newborn
Infant, Premature / physiology*
Models, Cardiovascular
Grant Support
5T32-HL-07284/HL/NHLBI NIH HHS; NIGMS 64640//PHS HHS; R01 GM064640/GM/NIGMS NIH HHS; R01 GM064640-05/GM/NIGMS NIH HHS; R01 GM064640-06/GM/NIGMS NIH HHS; R01 GM064640-07/GM/NIGMS NIH HHS

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