| Periodic heart rate decelerations in premature infants. | |
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MedLine Citation:
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PMID: 20407086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pacemaking system of the heart is complex; a healthy heart constantly integrates and responds to extracardiac signals, resulting in highly complex heart rate patterns with a great deal of variability. In the laboratory and in some pathological or age-related states, however, dynamics can show reduced complexity that is more readily described and modeled. Reduced heart rate complexity has both clinical and dynamical significance - it may provide warning of impending illness or clues about the dynamics of the heart's pacemaking system. In this paper, we describe simple and interesting heart rate dynamics that we have observed in premature human infants - reversible transitions to large-amplitude periodic oscillations - and we show that the appearance and disappearance of these periodic oscillations can be described by a simple mathematical model, a Hopf bifurcation. |
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Authors:
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Abigail A Flower; J Randall Moorman; Douglas E Lake; John B Delos |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-04-28 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
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Languages: eng Pagination: 531-8 Citation Subset: IM |
Affiliation:
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Structural, Computational Biology and Biophysics Program, University of Virginia, Charlottesville, VA 22903, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Clocks
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physiology Deceleration* Heart Conduction System / physiology* Heart Rate / physiology* Humans Infant Infant, Newborn Infant, Premature / physiology* Models, Cardiovascular Periodicity |
| Grant Support | |
ID/Acronym/Agency:
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5T32-HL-07284/HL/NHLBI NIH HHS; NIGMS 64640//PHS HHS; R01 GM064640-05/GM/NIGMS NIH HHS; R01 GM064640-06/GM/NIGMS NIH HHS; R01 GM064640-07/GM/NIGMS NIH HHS |
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