Document Detail

Periodic fever and erythema nodosum associated with MDS with trisomy 8: report of two cases and review of the literature.
MedLine Citation:
PMID:  20376686     Owner:  NLM     Status:  In-Process    
We report two cases of myelodysplastic syndrome (MDS) with trisomy 8 who had periodic fever and erythema nodosum (EN). A 74-year-old man showed periodic fever and EN. A diagnosis of MDS with trisomy 8 was made, and he was successfully treated with prednisolone (PSL). A 71-year-old man presented with intermittent fever, EN, and recurrent elevation of myogenic enzymes. Despite sustained inflammation, laboratory tests showed macrocytic anemia and thrombocytopenia. Marrow aspiration showed MDS with the chromosomal abnormality trisomy 8. He was successfully treated with PSL without repeated transient fever and elevation of creatine kinase. The results of a literature review of 35 cases of MDS with trisomy 8 and Behçet's disease-like symptoms, such as EN, oral ulcer and intestinal ulcer, suggest that the disease entity of "trisomy 8 syndrome" may be considered, and that it is an important differential diagnosis of periodic fever and EN.
Takanori Fujimura; Naoichiro Yukawa; Ran Nakashima; Yoshitaka Imura; Daisuke Kawabata; Takaki Nojima; Koichiro Ohmura; Takao Fujii; Takashi Usui; Tsuneyo Mimori
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Publication Detail:
Type:  Journal Article     Date:  2010-04-08
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  20     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan.
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