Document Detail

Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis.
MedLine Citation:
PMID:  9893298     Owner:  NLM     Status:  MEDLINE    
We report the first case of the syndrome of periodic adrenocorticotropin (ACTH) and vasopressin (ADH) discharge associated with focal glomerulosclerosis. Approximately 30 cases of this syndrome have so far been reported in Japan, but no cases associated with renal dysfunction have yet been reported. The patient, a 10-year-old Japanese boy, was referred to our hospital because of recurrent attacks of vomiting. He was diagnosed as having this syndrome from clinical and laboratory findings. While various drugs were tried to manage his vomiting attacks, only valproic acid appeared to be effective in reducing the frequency of the attacks. Chronic nephritis was manifested when the patient was 12 years old, which required treatment with continuous ambulatory peritoneal dialysis. Valproic acid was proved to be effective in reducing the number of attacks over 4 months.
W Yokoyama; M Fujieda; T Okada; H Maeda; M Ushida; Y Machida; K Naruse; A Maeda; H Wakiguchi; T Kurashige
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  40     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-04     Completed Date:  1999-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  600-3     Citation Subset:  IM    
Department of Pediatrics, Kochi Medical School, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / secretion*
Glomerulosclerosis, Focal Segmental / complications*,  pathology
Kidney Failure, Chronic / etiology,  pathology,  therapy
Valproic Acid / therapeutic use
Vasopressins / secretion*
Vomiting / complications*,  drug therapy,  metabolism
Reg. No./Substance:
11000-17-2/Vasopressins; 9002-60-2/Adrenocorticotropic Hormone; 99-66-1/Valproic Acid

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