Document Detail


Periodate oxidation studies of human pituitary follicle-stimulating hormone.
MedLine Citation:
PMID:  4314117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A preparation of human pituitary follicle-stimulating hormone was subjected to periodate oxidation, borohydride reduction and acid hydrolysis. Comparison of the analysis of the remaining intact carbohydrate and amino acid units with the analyses of the original material and identification of the carbohydrate fragments permit some structural assignments to the molecule of follicle-stimulating hormone. The results of radioimmunological assay of fragments of the molecule of follicle-stimulating hormone suggest that, although the carbohydrate component is essential for biological activity, it is not a requirement for immunological activity, which appears to be a function of the protein moiety.
Authors:
J F Kennedy; W R Butt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  115     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1969 Nov 
Date Detail:
Created Date:  1970-05-04     Completed Date:  1970-05-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Boron Compounds
Follicle Stimulating Hormone / analysis*
Hexosamines / analysis
Hexoses / analysis
Humans
Neuraminic Acids / analysis
Oxidation-Reduction*
Periodic Acid*
Pituitary Gland / analysis
Proteins
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Boron Compounds; 0/Hexosamines; 0/Hexoses; 0/Neuraminic Acids; 0/Proteins; 10450-60-9/Periodic Acid; 9002-68-0/Follicle Stimulating Hormone
Comments/Corrections

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