Document Detail


Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s).
MedLine Citation:
PMID:  22891330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daily rhythmic processes are coordinated by circadian clocks, which are present in numerous central and peripheral tissues. In mammals, two circadian clocks, the food-entrainable oscillator (FEO) and methamphetamine-sensitive circadian oscillator (MASCO), are "black box" mysteries because their anatomical loci are unknown and their outputs are not expressed under normal physiological conditions. In the current study, the investigation of the timekeeping mechanisms of the FEO and MASCO in mice with disruption of all three paralogs of the canonical clock gene, Period, revealed unique and convergent findings. We found that both the MASCO and FEO in Per1(-/-)/Per2(-/-)/Per3(-/-) mice are circadian oscillators with unusually short (∼21 h) periods. These data demonstrate that the canonical Period genes are involved in period determination in the FEO and MASCO, and computational modeling supports the hypothesis that the FEO and MASCO use the same timekeeping mechanism or are the same circadian oscillator. Finally, these studies identify Per1(-/-)/Per2(-/-)/Per3(-/-) mice as a unique tool critical to the search for the elusive anatomical location(s) of the FEO and MASCO.
Authors:
Julie S Pendergast; Gisele A Oda; Kevin D Niswender; Shin Yamazaki
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-13
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2012-12-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14218-23     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235-1634, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticipation, Psychological / physiology
Central Nervous System Stimulants / pharmacology
Circadian Rhythm / drug effects,  physiology*
Feeding Behavior / physiology*
Female
Food Deprivation / physiology
Male
Methamphetamine / pharmacology*
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Motor Activity / physiology
Period Circadian Proteins / genetics,  physiology*
Photoperiod
Suprachiasmatic Nucleus / physiology*
Grant Support
ID/Acronym/Agency:
DK085712/DK/NIDDK NIH HHS; DK20593/DK/NIDDK NIH HHS; R01 DK085712/DK/NIDDK NIH HHS; U24DK076169/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Per1 protein, mouse; 0/Per2 protein, mouse; 0/Per3 protein, mouse; 0/Period Circadian Proteins; 537-46-2/Methamphetamine
Comments/Corrections

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