Document Detail


Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty.
MedLine Citation:
PMID:  7684663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
FK-506 is a new immunosuppressant with the ability to inhibit activation of T-lymphocytes that would be cytolytic to an allograft. We studied periocular injection of FK-506 in a rat penetrating keratoplasty model. Corneas were transplanted from Brown Norway rats into Lewis rat recipients. The transplanted rats received periocular injection of either 0.5 mg/kg FK-506 or an equivalent volume of FK-506 vehicle only. Injections were given 1 day before, at keratoplasty, and every other day after keratoplasty until allograft rejection. The group receiving FK-506 had a significant delay in allograft rejection (p < 0.05). The FK-506 group rejected 12-20 days postkeratoplasty with a mean rejection time (MRT) of 14.3 days, compared with 8-14 days (MRT 11.1 days) for the control group. We conclude that periocular administration of FK-506 is effective in prolonging allograft survival in the rat penetrating keratoplasty model.
Authors:
J B Dickey; E M Cassidy; C S Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cornea     Volume:  12     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-28     Completed Date:  1993-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-7     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Loyola University Medical Center, Maywood, Illinois 60153.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Graft Rejection / etiology,  prevention & control*
Injections
Keratoplasty, Penetrating* / adverse effects
Orbit
Premedication
Rats
Rats, Inbred BN
Rats, Inbred Lew
Tacrolimus / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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