Document Detail

Perinuclear and cytoplasmic distribution of desmoglein in esophageal squamous cell carcinomas.
MedLine Citation:
PMID:  11261822     Owner:  NLM     Status:  MEDLINE    
The desmosomal glycoproteins desmoglein (Dsg) and desmocollin (Dsc) are members of the cadherin family of cell adhesion molecules. They play an important role in epithelial adhesion. To observe the distribution pattern of Dsg in esophageal squamous cell carcinomas (SCC), immunohistochemical and immunoelectron microscopic analyses were performed. Immunohistochemically, normal esophageal squamous cells strongly expressed Dsg at the cell-cell boundaries, while moderately differentiated esophageal SCC cells showed a perinuclear distribution in addition to the cell boundary staining. At the ultrastructural level, the reaction product was concentrated at the desmosomes in the cell membrane region of normal epithelial cells, but was reduced at the membrane and found throughout the cytoplasm as well as in the surrounding outer nuclear envelope in SCC cells. These results demonstrate an aberrant distribution of Dsg in SCC cells. This may have important consequences for invasion and metastasis, as it may indicate loosened intercellular adhesion.
F Pittella; K Katsube; T Takemura; T Hashimoto; T Kawano; D Garrod; M Takagi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology, research and practice     Volume:  197     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Division of Molecular Pathology, Graduate School, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / chemistry*,  secondary
Cell Nucleus / chemistry*
Cytoplasm / chemistry*
Cytoskeletal Proteins / analysis*
Desmosomes / chemistry,  ultrastructure
Epithelial Cells / chemistry,  cytology,  pathology
Esophageal Neoplasms / chemistry*,  pathology
Esophagus / anatomy & histology,  chemistry,  pathology
Immunoenzyme Techniques
Lymph Nodes / pathology
Lymphatic Metastasis
Microscopy, Immunoelectron
Middle Aged
Neoplasm Staging
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Desmocollins; 0/Desmogleins; 0/Desmoplakins

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