Document Detail

Perineural extension to the skull base from early cutaneous malignancies of the midface.
MedLine Citation:
PMID:  17967638     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To document the clinical progression of four patients with a past history of complete removal of early midface cutaneous malignancies that presented years later with isolated recurrence along the distribution of the infraorbital nerve, and to discuss the diagnostic role of early imaging to identify perineural invasion. STUDY DESIGN: The study is a retrospective chart review, review of radiographic findings, and review of the literature. RESULTS: The authors report four cases of isolated perineural invasion along the infraorbital nerve resulting from previously excised cutaneous malignancies. CONCLUSIONS: Pain followed by anesthesia in the distribution of second division of the trigeminal nerve should alert the practitioner about possible perineural recurrence that may require imaging and open exploration to establish the diagnosis.
Tapan A Padhya; Rebecca S Cornelius; Sanjay M Athavale; Jack L Gluckman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  137     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, University of South Florida College of Medicine, Tampa, FL 33612, USA.
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MeSH Terms
Disease Progression
Facial Neoplasms / pathology*,  surgery
Magnetic Resonance Imaging
Neoplasm Invasiveness / pathology
Retrospective Studies
Skin Neoplasms / pathology*,  surgery
Skull Base / pathology
Skull Base Neoplasms / diagnosis,  pathology*
Trigeminal Nerve

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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