| Perindopril decreases P wave dispersion in patients with stage 1 hypertension. | |
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MedLine Citation:
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PMID: 19502255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Angiotensin-converting enzyme inhibitors prevent atrial fibrillation episodes by effective control of blood pressure and improving electrical and structural remodelling in the atria. Increased P wave dispersion (PWD) is a non-invasive electrocardiographic marker for paroxysmal atrial fibrillation. The aim of the study was to evaluate the effect of perindopril treatment on PWD in hypertensive patients. METHODS: Forty-eight hypertensive patients (mean age 57.4+/-11.8 years, 18 men) were included. Blood pressure values were determined and 12-lead electrocardiograms were recorded at the beginning and at the first week, first month, third month and sixth month of the perindopril treatment.The difference between maximum and minimum P wave durations was calculated as PWD. RESULTS: PWDs were significantly shortened at the first, third and sixth months (41.7+/-8.8 ms, 39.1+/-6.9 ms and 38.3+/-7.1 ms, respectively) compared with baseline and first-week measurements (54.3+/-9.2 ms and 49.0+/-9.1 ms, respectively, p<0.001). Baseline PWD was correlated with body mass index (r=0.32, p=0.026), while PWD at the sixth month of treatment was significantly correlated with left atrial volume index (r=0.30, p=0.042). Multiple linear regression analysis revealed that PWD at the sixth month was related to baseline PWD (p=0.001). CONCLUSION: Perindopril treatment significantly reduced PWD in hypertensive patients. |
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Authors:
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Beste Ozben; Mutlu Sumerkan; Azra Meryem Tanrikulu; Nurdan Papila-Topal; Ali Serdar Fak; Ahmet Toprak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 10 ISSN: 1470-3203 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-08-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 85-90 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. bestes@doctor.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Atrial Fibrillation / drug therapy, physiopathology Echocardiography / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Perindopril / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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