Document Detail


Perinatal undernutrition stimulates seeking food reward.
MedLine Citation:
PMID:  23669181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiments in animals have revealed that perinatal nutritional restriction, which manifests in adulthood, increases food intake and preference for palatable foods. Considering this, we aimed to evaluate the effects of perinatal malnutrition on hedonic control of feeding behavior. In this study, we divided Wistar rats into two groups according to the diet provided to their mothers during pregnancy and lactation: the control group (diet with 17% casein) and low-protein group (diet with 8% casein). We assessed the animals' motivational behavior in adulthood by giving them a stimulus of food reward. We also assessed their neuronal activation triggered by the stimulus of palatable food using FOS protein labeling of neurons activated in the caudate putamen, paraventricular, dorsomedial, ventromedial, and lateral hypothalamic nuclei and amygdala. Evaluation of body weight in malnourished animals showed reduction from the 6th day of life until adulthood. Analysis of feeding behavior revealed that these animals were more motivated by food reward, but they had delays during learning of the task. This finding correlated with the number of c-FOS-immunoreactive neurons, which indicated that malnourished animals had an increase in the number of neurons activated in response to the palatable diet, especially in the amygdala and caudate putamen. The study therefore confirmed our hypothesis that early nutritional insults promote changes in encephalic control mechanisms, especially those related to food intake and search for reward.
Authors:
Amanda Alves Marcelino da Silva; Tássia Karin Ferreira Borba; Lívia de Almeida Lira; Taisy Cinthia Ferro Cavalcante; Manuela Figueiroa Lyra de Freitas; Carol Gois Leandro; Elizabeth do Nascimento; Sandra Lopes de Souza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-11
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  31     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2014-01-08     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Proteins / metabolism*
Eating*
Feeding Behavior*
Female
Male
Malnutrition / physiopathology*
Pregnancy
Prenatal Exposure Delayed Effects / physiopathology*
Rats
Rats, Wistar
Reward*
Chemical
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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