Document Detail


Perinatal transmission of hepatitis B virus in Senegal, west Africa.
MedLine Citation:
PMID:  8476509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 152 healthy pregnant women and their 156 newborns for markers of hepatitis B virus (HBV) infection in Dakar, Senegal. Of these, 120 mothers (79%) had antibodies to the hepatitis B core antigen (anti-HBc), 21 (13.8%) were hepatitis B surface antigen (HBs Ag) positive, including 2/21 (9.5%) hepatitis B core-associated antigen (HBe Ag) positive and 1/21 (4.7%) HBV DNA positive. At birth, 11 (7%) infants were HBs Ag positive; 9/11 had an HBs Ag positive mother. Ten of these HBs Ag positive-born infants were investigated at 6-7 months: 5 were strongly HBs Ag positive and developed antibodies to HBs Ag, HBc Ag or HBe Ag; these 5 (3.2% of the total) probably became chronic carriers of HBV. The 5 others were HBs Ag negative and 4/5 did not develop antibodies against HBV Ag; HBs Ag positivity at birth was likely due to contamination of the mother's blood. Thirty-one of the 145 HBs Ag negative-born infants were studied at 6-7 months and remained HBs Ag negative. However, 5 (16%) showed evidence of HBV infection occurring between 0 and 6 months, as shown by the development of antibodies to HBs Ag, HBc Ag, and/or HBe Ag. Despite the low prevalence of HBV DNA and HBe Ag in HBs Ag positive African mothers, this study shows the occurrence of perinatal transmission of HBV in West Africa, in contrast with previous studies. Perinatal HBV transmission could explain the HBV vaccination failure recently reported in children in Senegal.
Authors:
P Roingeard; A Diouf; J L Sankale; C Boye; S Mboup; F Diadhiou; M Essex
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Viral immunology     Volume:  6     ISSN:  0882-8245     ISO Abbreviation:  Viral Immunol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Carrier State
DNA, Viral / analysis
Diseases in Twins
Female
Hepatitis B / congenital,  epidemiology,  transmission*
Hepatitis B Antibodies / blood
Hepatitis B Antigens / blood
Hepatitis B virus / immunology,  isolation & purification
Humans
Infant, Newborn
Maternal-Fetal Exchange*
Pregnancy
Pregnancy Complications, Infectious* / epidemiology
Prevalence
Senegal / epidemiology
Grant Support
ID/Acronym/Agency:
CA-39805/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Antibodies; 0/Hepatitis B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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