Document Detail

Perinatal transmission of hepatitis B virus and its prevention.
MedLine Citation:
PMID:  10921375     Owner:  NLM     Status:  MEDLINE    
In order to prevent liver cirrhosis and hepatocellular carcinoma in later life, it is essential to prevent HBV infection in infants. If the mother is chronically infected with HBV and is also positive for HBeAg, 80-90% of the newborns become chronically infected, whereas if the mother is positive for anti-HBe, only some newborns will develop acute hepatitis or fulminant hepatitis. It is necessary to screen pregnant women for HBsAg and prevent mother-to-infant infection of HBV, treating the infant with hepatitis B hyperimmune globulin at birth, followed by HBV vaccination. In highly endemic areas of HBV, universal HBV vaccination of all newborns is advisable.
K Shiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  15 Suppl     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  E11-5     Citation Subset:  IM    
Department of Paediatrics, Faculty of Medicine, Tottori University, Yonago, Japan.
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MeSH Terms
Carrier State / epidemiology
Hepatitis B / epidemiology,  transmission
Hepatitis B Surface Antigens / analysis
Hepatitis B, Chronic / diagnosis,  epidemiology,  prevention & control*
Immunoglobulins, Intravenous / administration & dosage
Infant, Newborn
Japan / epidemiology
Pregnancy Complications, Infectious / diagnosis*
Taiwan / epidemiology
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Immunoglobulins, Intravenous

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