| Perinatal thermogenesis. | |
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MedLine Citation:
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PMID: 7493585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rapid initiation of thermogenesis is crucial for the survival of newborn infants. At birth the fetus must adapt to cooling, increased oxygenation and separation from the placenta. An experimental approach in the chronically instrumental fetal sheep of 'simulated birth in utero' allowed the evaluation of each of these stimuli sequentially. Cooling stimulated shivering, cardiovascular and endocrine responses but not nonshivering thermogenesis (NST). Ventilation of the cooled fetus with oxygen caused only modest NST which was not altered by an infusion of triiodothyronine. Occluding the umbilical cord was followed by a rapid substantial rise in NST which was maintained until the placental circulation was re-established. Thus the placenta is secreting factors into the fetal circulation which inhibit the ability of the brown adipose tissue to respond to either hormonal or neural stimuli. Placental prostaglandin E2 and probably adenosine are tonic inhibitors of thermogenesis in utero. Effective thermogenesis after birth requires the combination of separation from the placental inhibitors of lipolysis, increased oxygenation from breathing and the stimulation of cutaneous cold receptors. |
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Authors:
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T R Gunn; P D Gluckman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Early human development Volume: 42 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-01-11 Completed Date: 1996-01-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 169-83 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, School of Medicine, University of Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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physiology Adipose Tissue, Brown / physiology Animals Animals, Newborn / physiology* Body Temperature Regulation / drug effects, physiology* Cold Temperature Dinoprostone / physiology Fetus / blood supply, physiology* Oxygen / administration & dosage Placenta / blood supply, physiology Sheep / embryology, physiology Shivering |
| Chemical | |
Reg. No./Substance:
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363-24-6/Dinoprostone; 58-61-7/Adenosine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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