Document Detail

Perinatal salt restriction: a new pathway to programming adiposity indices in adult female Wistar rats.
MedLine Citation:
PMID:  18289603     Owner:  NLM     Status:  MEDLINE    
Low birth weight has been associated with increased obesity in adulthood. It has been shown that dietary salt restriction during intrauterine life induces low birth weight and insulin resistance in adult Wistar rats. The present study had a two-fold objective: to evaluate the effects that low salt intake during pregnancy and lactation has on the amount and distribution of adipose tissue; and to determine whether the phenotypic changes in fat mass in this model are associated with alterations in the activity of the renin-angiotensin system. Maternal salt restriction was found to reduce birth weight in male and female offspring. In adulthood, the female offspring of dams fed the low-salt diet presented higher adiposity indices than those seen in the offspring of dams fed a normal-salt diet. This was attributed to the fact that adipose tissue mass (retroperitoneal but not gonadal, mesenteric or inguinal) was greater in those rats than in the offspring of dams fed a normal diet. The adult offspring of dams fed the low-salt diet, compared to those dams fed a normal-salt diet, presented the following: plasma leptin levels higher in males and lower in females; plasma renin activity higher in males but not in females; and no differences in body weight, mean arterial blood pressure or serum angiotensin-converting enzyme activity. Therefore, low salt intake during pregnancy might lead to the programming of obesity in adult female offspring.
Karen L Lopes; Luzia N S Furukawa; Ivone B de Oliveira; Miriam S Dolnikoff; Joel C Heimann
Related Documents :
7163403 - Effects of high fat, protein supplemented diets on maternal behavior in rats.
7104413 - Role of milk-borne factors in weaning and intestinal development.
20699423 - Niemann-pick c1-like 1 deletion in mice prevents high-fat diet-induced fatty liver by r...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-26
Journal Detail:
Title:  Life sciences     Volume:  82     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-14     Completed Date:  2008-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  728-32     Citation Subset:  IM    
Department of Internal Medicine, Laboratory of Experimental Hypertension of the University of São Paulo School of Medicine, 01246-903 São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / growth & development
Adiposity / physiology*
Blood Pressure / physiology
Diet, Sodium-Restricted / adverse effects*
Leptin / blood
Prenatal Exposure Delayed Effects / enzymology,  etiology*,  metabolism,  physiopathology
Rats, Wistar
Renin / blood,  metabolism
Renin-Angiotensin System / physiology
Sex Factors
Sodium Chloride, Dietary / administration & dosage
Reg. No./Substance:
0/Leptin; 0/Sodium Chloride, Dietary; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A contemporary study correlating prostate needle biopsy and radical prostatectomy Gleason score.
Next Document:  Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.