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Perinatal role of hepcidin and iron homeostasis in full-term intrauterine growth restricted infants.
MedLine Citation:
PMID:  23110713     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To prospectively investigate iron homeostasis in full-term intrauterine-growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) infants at birth, by evaluating cord blood concentrations of hepcidin (a bioactive molecule, principal regulator of iron metabolism, downregulated by hypoxia/iron deficiency and upregulated by inflammation), erythropoietin (EPO, a marker of prolonged fetal hypoxia), soluble transferrin receptor (sTfR, a marker of increased erythropoiesis and tissue iron deficiency), iron, ferritin and unsaturated iron-binding capacity-(UIBC). METHODS: Serum cord blood samples from 47 well-defined IUGR and 104 AGA singleton full-term infants were analysed for concentrations of all above parameters by enzyme immunoassays and spectrophotometry. RESULTS: Hepcidin concentrations were similar, while EPO concentrations were higher in IUGR cases than AGA controls (P=0.047). Cord blood sTfR concentrations were increased in IUGR, compared to AGA infants (P=0.004) and negatively correlated with their customized centiles and birth-weight (r=-0.238, P=0.003 and r=-0.157, P=0.050, respectively). Ferritin concentrations were lower in IUGR cases than AGA controls (P=0.039). In both groups, no correlations were observed between cord blood hepcidin concentrations and iron status indices. CONCLUSIONS: Cord blood hepcidin concentrations in term IUGRs may remain unaffected, possibly due to a balance between hepcidin downregulation by chronic fetal hypoxia (indicated by higher EPO concentrations) and impaired iron metabolism (indicated by lower ferritin and higher sTfR concentrations) on the one hand, and hepcidin upregulation by the inflammatory state characterizing IUGRs, on the other. Furthermore, our findings may possibly indicate the need for regular follow-up for detection of iron deficient anemia, not only in preterm, but also in full-term IUGR neonates. © 2012 John Wiley & Sons A/S.
Authors:
Despina D Briana; Theodora Boutsikou; Stavroula Baka; Maria Boutsikou; Lamprini Stamati; Dimitrios Hassiakos; Dimitrios Gourgiotis; Ariadne Malamitsi-Puchner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-30
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
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