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Perinatal risk factors for neurocognitive impairments in preschool children born very preterm.
MedLine Citation:
PMID:  23320575     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim  This study aimed to compare a broad array of neurocognitive functions (processing speed, aspects of attention, executive functioning, visual-motor coordination, and both face and emotion recognition) in very preterm and term-born children and to identify perinatal risk factors for neurocognitive dysfunctions. Method  Children who were born very preterm (n=102; 46 males, 56 females), defined as a gestational age of less than 30 weeks and/or birthweight under 1000g, and a comparison group of term-born children (n=95; 40 males, 55 females) were assessed at age 5 with the Wechsler Preschool and Primary Scale of Intelligence, Stop Signal Task, several tasks of the Amsterdam Neuropsychological Tasks, and a Digit Span task. Results  When sociodemographic characteristics were taken into account, very preterm children scored worse than term-born children on all neurocognitive functions, except on tasks measuring inhibition and sustained attention, for which results were inconclusive. Effect sizes for group effects were small to medium (r(2) varying between 0.02 and 0.07). Principal component isolated four factors: visual-motor coordination, face/emotion recognition, reaction time/attention, and accuracy/attention. When sociodemographic and child characteristics at birth were accounted for, bronchopulmonary dysplasia was significantly negatively associated with all four components and also with working memory. Interpretation  Very preterm children are at risk for problems on a broad array of neurocognitive functions. Bronchopulmonary dysplasia is an independent risk factor for impaired neurocognitive functioning.
Authors:
Eva S Potharst; Aleid G VAN Wassenaer-Leemhuis; Bregje A Houtzager; David Livesey; Joke H Kok; Bob F Last; Jaap Oosterlaan
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  55     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  178-184     Citation Subset:  -    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
Affiliation:
 Psychosocial Department, Emma's Children's Hospital Academic Medical Centre, Amsterdam;  Department of Neonatology, Emma's Children's Hospital Academic Medical Centre, Amsterdam;  Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam;  Medical Psychology, Deventer Hospital, Deventer, the Netherlands.  School of Psychology, The University of Sydney, Sydney, NSW, Australia.  Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, the Netherlands.
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