Document Detail


Perinatal risk factors in offenders with severe personality disorder: a population-based investigation.
MedLine Citation:
PMID:  23013342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although perinatal factors are associated with the development of several psychiatric disorders, it is unknown whether these factors are linked with personality disorder. Cases of personality disorder were drawn from a national registry of all forensic psychiatric evaluations (n = 150). Two control groups were used: (1) A sample of forensic evaluations without any psychiatric disorder (n = 97) allowing for a nested case-control investigation; and (2) A population-based sample matched by age and gender with no history of psychiatric hospitalization (n = 1498). Prematurity (<37 weeks of completed gestation) was significantly associated with a diagnosis of personality disorder, both in the nested and the population-based case-control comparisons with adjusted odds ratios (OR) for this risk factor ranging from 2 to 4. Asphyxia (adjusted OR = 2.4, 95% CI: 1.4-4.1) and complicated delivery (adjusted OR = 1.5, 1.0-2.1) were associated with personality disorder in the population-based study, and the former remained significant in multivariate models. Overall, perinatal complications were found to be associated with a later diagnosis of personality disorder in this selected sample. As with other psychiatric disorders where such associations have been demonstrated, changes during the perinatal period may lead to abnormal brain development and function.
Authors:
Seena Fazel; Liliya Bakiyeva; Sven Cnattingius; Martin Grann; Christina M Hultman; Paul Lichtenstein; John R Geddes
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of personality disorders     Volume:  26     ISSN:  1943-2763     ISO Abbreviation:  J. Pers. Disord.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-27     Completed Date:  2013-02-22     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8710838     Medline TA:  J Pers Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-50     Citation Subset:  IM    
Affiliation:
University of Oxford, Warneford Hospital, Oxford, UK. seena.fazel@psych.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asphyxia Neonatorum / complications*,  epidemiology
Case-Control Studies
Criminals / psychology*
Female
Humans
Infant, Low Birth Weight / psychology*
Infant, Newborn
Infant, Premature
Male
Obstetric Labor Complications / epidemiology*
Personality Disorders / epidemiology,  etiology*
Pregnancy
Registries*
Risk Factors
Severity of Illness Index
Sweden / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
R01 HD061817/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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