Document Detail

Perinatal predictors of neurodevelopmental outcome in small-for-gestational-age children at 18 months of age.
MedLine Citation:
PMID:  12015539     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to explore the influence of a range of perinatal variables on neurodevelopment at 18 months in a cohort of small-for-gestational-age (SGA) children born in the mid 1990s. STUDY DESIGN: Two hundred eighty-two SGA children (birth weight <10th centile) were followed up prospectively; 220 (78%) had Bayley Scales of Infant Development II performed at 18 months' corrected age. RESULTS: The mean (SD) gestation at delivery was 36.5 (2.7) weeks and mean birth weight was 2095 (549) g. The mean Bayley Scales of Infant Development scores were as follows: Mental Developmental Index score, 95.6 (14.5); Psychomotor Developmental Index score, 97.9 (14.8); and Behavioural Rating Scale score, 110.6 (13.5). SGA children whose mothers had pregnancy-induced hypertension were less likely to have low Mental Development Index scores than SGA children whose mothers were normotensive during pregnancy (10 [23%] vs 78 [44%]. P =.01). Low Psychomotor Development Index scores were associated with not being breast-fed at 3 months (odds ratio [OR] 3.5; 95% CI 1.2-10.1) and long neonatal nursery stay (OR 2.8, 95% CI 1.02-7.05). A low Behavioral Rating Scale score was associated with a large z score for head circumference at birth (OR 2.4, 95% CI 1.2-4.8) and cord arterial base deficit (OR 1.2, 95% CI 1.01-1.4). CONCLUSION: Few of the perinatal variables previously reported are predictive of early childhood outcome in this modern cohort of SGA infants.
Lesley M E McCowan; Jan Pryor; Jane E Harding
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1069-75     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University of Auckland, New Zealand
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MeSH Terms
Breast Feeding
Child Development*
Cohort Studies
Fetus / physiology*
Hypertension / complications
Infant Behavior
Infant, Newborn / physiology*
Infant, Small for Gestational Age / growth & development*,  physiology,  psychology
Mental Retardation / etiology
Nervous System / growth & development*
Pregnancy Complications, Cardiovascular
Psychomotor Performance
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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