Document Detail


Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice.
MedLine Citation:
PMID:  17938543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia. METHODS: Pregnant mice were exposed to BPA in drinking water at concentrations of either 1 microg/mL (LD group) or 10 microg/mL (HD group) from gestation day 10 and throughout the lactating period. After weaning, the pups were allowed free access to drinking water containing the appropriate concentrations of BPA. The body weight, adipose tissue weight, and serum lipid levels were measured in the offspring at postnatal day 31. RESULTS: In females, the mean body weight increased by 13% in the LD group (p<0.05) and 11% in the HD group (p<0.05) compared with the control group. The mean adipose tissue weight increased by 132% in the LD group (p<0.01). The mean total cholesterol level increased by 33% in the LD group (p<0.01) and 17% in the HD group (p<0.05). In males, the mean body weight and mean adipose tissue weight increased by 22% (p<0.01) and 59% (p<0.01), respectively, in the HD group compared with the control group. The mean triacylglycerol level increased by 34% in the LD group (p<0.05). CONCLUSIONS: The continuous exposure of mice to BPA during the perinatal and postnatal periods caused the development of obesity and hyperlipidemia.
Authors:
Joji Miyawaki; Kenshi Sakayama; Hideo Kato; Haruyasu Yamamoto; Hiroshi Masuno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-12
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  14     ISSN:  1340-3478     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-07     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  245-52     Citation Subset:  IM    
Affiliation:
Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects*
Animals
Blood Glucose / drug effects
Body Weight / drug effects*
Cholesterol / blood*
Estrogens, Non-Steroidal / toxicity*
Female
Hyperlipidemias / chemically induced
Leptin / blood
Male
Mice
Obesity / chemically induced
Phenols / toxicity*
Pregnancy
Prenatal Exposure Delayed Effects*
Sex Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Estrogens, Non-Steroidal; 0/Leptin; 0/Phenols; 57-88-5/Cholesterol; 80-05-7/bisphenol A

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