Document Detail

Perinatal physiology in cloned and normal calves: physical and clinical characteristics.
MedLine Citation:
PMID:  17386015     Owner:  NLM     Status:  MEDLINE    
The period immediately after birth is a vital time for all newborn calves as the cardiovascular, respiratory, and other organ systems adapt to life ex utero. Reported neonatal mortality rates suggest this period to be especially critical in cloned calves; yet prospective, controlled studies on the physiological status of these calves are lacking. The objectives of this study were to compare neonatal (birth to 48 h of age) physical and clinical characteristics and placental morphology of cloned and embryo transfer control calves delivered by cesarean section after induced labor. All calves were raised under specialized neonatal-care protocols at a large-animal veterinary research and teaching hospital. Cloned calves were similar to controls for many parameters studied. Notable exceptions included developmental delays of important physical adjustment parameters and enlargement of the umbilical region. Placentas associated with cloned calves contained fewer total placentomes, a twofold increase in surface area and mass per placentome, and a shift in placentome morphology toward larger, flatter placentomes. The most striking clinical variations detected in clones were hypoglycemia and hyperfructosemia, both measures of carbohydrate metabolism. Because the placenta is known to be the source of plasma fructose in newborn calves, increased fructose production by the cloned placenta may be an important factor in the etiology of umbilical and cardiac anomalies in clones observed in this and other studies.
Cynthia A Batchelder; Marcelo Bertolini; Jeffrey B Mason; Alice L Moyer; Kara A Hoffert; Stoyan G Petkov; Thomas R Famula; John Angelos; Lisle W George; Gary B Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cloning and stem cells     Volume:  9     ISSN:  1536-2302     ISO Abbreviation:  Cloning Stem Cells     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125444     Medline TA:  Cloning Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-82     Citation Subset:  IM    
Department of Animal Science, University of California, Davis, Davis, California 95616, USA.
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MeSH Terms
Animals, Newborn / abnormalities*,  metabolism
Carbohydrate Metabolism*
Cattle / abnormalities*,  metabolism
Cattle Diseases / blood,  pathology,  physiopathology*
Cloning, Organism / adverse effects*
Heart Diseases / blood,  pathology,  physiopathology*,  veterinary
Placenta / abnormalities,  physiopathology

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