| Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection. | |
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MedLine Citation:
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PMID: 16519618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI). DESIGN: Retrospective case-control study. PATIENTS: Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital. MAIN OUTCOME MEASURES: Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension. RESULTS: Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age. CONCLUSION: Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins. |
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Authors:
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Burcu Saygan-Karamürsel; Ozlem Tekşam; Tarik Aksu; Murat Yurdakök; Lütfü Onderoğlu |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 34 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2006 |
Date Detail:
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Created Date: 2006-03-07 Completed Date: 2006-09-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 132-8 Citation Subset: IM |
Affiliation:
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Hacettepe University Department of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey. Bkaramursel@mesa.com.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Congenital Abnormalities / epidemiology Female Humans Infant Mortality Infant, Newborn Infant, Newborn, Diseases / epidemiology Pregnancy Pregnancy Outcome* Retrospective Studies Sperm Injections, Intracytoplasmic* Twins* |
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