Document Detail

Perinatal outcome of recurrent pre-eclampsia versus pre-eclampsia in nulliparas.
MedLine Citation:
PMID:  20144169     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the study was to compare the perinatal outcome of recurrent pre-eclampsia in multiparas with that of pre-eclampsia in nulliparas.
METHODS: This retrospective study was performed by collecting maternal and perinatal data from records of women with pre-eclampsia who delivered at Mackay Memorial Hospital over a 10-year period. Fifty women with recurrent pre-eclampsia were compared with 207 women who developed pre-eclampsia as nulliparas. In the 50 multiparas, the outcome of recurrent pre-eclampsia was also compared with that of their earlier episodes of pre-eclampsia. Maternal and fetal variables compared included maternal blood pressure, serum biochemistry, rate of preterm delivery, rate of abruptio placentae and neonatal outcome.
RESULTS: Compared with nulliparous women with pre-eclampsia (n = 50), women with recurrent pre-eclampsia (n = 207) had a smaller increase in mean maternal blood pressure (27.0 +/- 18.9 mmHg vs 34.3 +/- 19.3 mmHg, P = 0.021), less dipstick proteinuria (>or=++; 36.0 vs 58.5%, P = 0.004), and bore children with a heavier mean birthweight (2909.1 +/- 895.5 g vs 2551.1 +/- 933.0 g, P = 0.017). No significant statistical difference was found in the gestational age of delivery, maternal serum biochemical levels and rate of abruptio placentae or preterm delivery. Within the multiparous group (n = 50), recurrent disease was associated with a lower mean maternal blood pressure and dipstick proteinuria and with higher birthweight than in their previous pre-eclamptic pregnancies.
CONCLUSION: Recurrent pre-eclampsia appears to be less severe and to have a better perinatal outcome than pre-eclampsia in nulliparas.
Yi-Yung Chen; Mao-Lin Wu; Mei-Hua Kao; Tsung-Hsien Su; Chie-Pein Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  35     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-25     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1042-6     Citation Subset:  IM    
Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Infant, Newborn
Pre-Eclampsia / physiopathology*
Pregnancy Outcome*
Retrospective Studies

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