Document Detail

Perinatal outcome and prognostic factors in prenatally diagnosed congenital diaphragmatic hernia.
MedLine Citation:
PMID:  9744054     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess perinatal outcome in cases of prenatally diagnosed congenital diaphragmatic hernia and identify the prognostic value of various prenatal factors. DESIGN: Retrospective review of fetal medicine, obstetric and histopathology records in all 34 cases of congenital diaphragmatic hernia identified prenatally between 1992 and 1996 at a tertiary referral fetal medicine unit. RESULTS: Overall survival was 18%. None of those with bilateral (0/1) or right-sided (0/5) congenital diaphragmatic hernia survived, whereas 21% (6/28) of those with left-sided hernias survived. Prenatal karyotyping was performed in 71% (n = 24) and five chromosomal abnormalities were identified. The pregnancy was terminated in 15 cases (44%). In the 19 continuing pregnancies, the survival rate was 32% (6/19). In those with an isolated congenital diaphragmatic hernia, the survival rate was 38% (5/13), and in those in which the hernia was isolated and left-sided, the survival rate was 56% (5/9). In ongoing pregnancies diagnosed after 24 weeks, the survival rate was 33% (2/6) compared with 31% (4/13) in pregnancies diagnosed at < or = 24 weeks. Of those infants who had surgical repair, six out of seven (86%) survived. CONCLUSIONS: These data clearly demonstrate an improved prognosis in fetuses with an isolated left-sided congenital diaphragmatic hernia.
M P Geary; L S Chitty; J J Morrison; V Wright; A Pierro; C H Rodeck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  12     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-04     Completed Date:  1998-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Fetal Medicine Unit, Obstetric Hospital, University College London Hospitals, UK.
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MeSH Terms
Hernia, Diaphragmatic / congenital,  mortality,  ultrasonography*
Infant, Newborn
Pregnancy Outcome
Retrospective Studies
Survival Rate
Ultrasonography, Prenatal*

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