Document Detail

Perinatal outcome for pregnancies complicated with thrombocytopenia.
MedLine Citation:
PMID:  22220678     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns.
OBJECTIVE: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia.
METHODS: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period.
RESULTS: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery - highest risk for severe thrombocytopenia (RR=8.69, p<0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR=7.97, p=0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia - 2047.50 ± 938.98 g (p=0.02) versus 3224.86 ± 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR=11.94, p=0.00), with medium weight of 2462.05 ± 794.54 g versus 2932.37 ± 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 ± 496.00 g (p=0.00) in normal pregnancies.
CONCLUSIONS: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome - for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetus/newborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention.
Minodora Onisâi; Ana-Maria Vlădăreanu; Caterina Delcea; Mihai Ciorăscu; Horia Bumbea; Anca Nicolescu; Irina Voican; Alexandru Filipescu; Octavian Rotaru; Radu Vlădăreanu
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Publication Detail:
Type:  Journal Article     Date:  2012-02-14
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2013-01-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1622-6     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
HELLP Syndrome / epidemiology,  mortality
Infant, Newborn
Infant, Premature, Diseases / epidemiology,  mortality
Obstetric Labor, Premature / epidemiology,  mortality
Perinatal Mortality
Pre-Eclampsia / epidemiology,  mortality
Pregnancy Complications, Hematologic / epidemiology*,  mortality
Pregnancy Outcome / epidemiology*
Retrospective Studies
Thrombocytopenia / epidemiology*,  mortality
Young Adult

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