Document Detail

Perinatal outcome prediction by maternal homocysteine and uterine artery Doppler velocimetry.
MedLine Citation:
PMID:  15036713     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: (a) To evaluate the predictive value of uterine Doppler velocimetry for pregnancy complications, (b) to study the relationship between abnormal uterine Doppler velocimetry and plasma homocysteine, and (c) to determine whether homocysteine measurement improves the predictive value of uterine Doppler screening. STUDY DESIGN: Prospective study including 94 pregnant women without previous risk factors. Total homocysteine, folate and Vitamin B(12) were analysed. Uterine Doppler velocimetry at weeks 24-25 was performed. RESULTS: The presence of any uterine Doppler alteration had a sensitivity of 66.7%, and a specificity of 81.2%, in predicting obstetric complications. The likelihood ratio was 3.6. The positive and negative predictive values were 27.3 and 95.8%, respectively. The global efficiency was 83.0%. The addition of hyperhomocysteinemia to Doppler alterations increased the sensitivity from 66.7 to 77.8%. CONCLUSIONS: The addition of homocysteine determination to uterine Doppler evaluation in the second trimester does not usefully improve its predictive value.
Eva López-Quesada; M Antonia Vilaseca; Antonio Vela; Josep M Lailla
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  113     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Obstetrics and Gynecology Department, Hospital Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Passeig Sant Joan de Déu 2, Barcelona 08950, Spain.
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MeSH Terms
Arteries / physiology
Blood Flow Velocity
Fetal Growth Retardation / blood,  physiopathology,  ultrasonography
Folic Acid / blood
Homocysteine / blood*
Laser-Doppler Flowmetry / methods*
Predictive Value of Tests
Pregnancy Complications / blood,  physiopathology,  ultrasonography*
Pregnancy Outcome
Prospective Studies
Sensitivity and Specificity
Uterus / blood supply*
Vitamin B 12 / blood
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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