| Perinatal outcome of illicit substance use in pregnancy-comparative and contemporary socio-clinical profile in the UK. | |
| | |
MedLine Citation:
|
PMID: 20827558 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The aim of the study was to determine the contemporary socio-clinical profile and perinatal outcome of illicit substance use in pregnancy in a large UK city and compare with published literature. Cases were identified retrospectively from the 'cause for concern' referrals over 5 years (2003-2007). Data was collected on mother-infant pair from medical notes and laboratory records. Chi-square and Mann-Whitney U tests were used where appropriate for statistical analysis. One hundred sixty-eight women were identified as using illicit substance in pregnancy. Smoking (97.4%), unemployment (85.4%) and single status (42.3%) were frequent. Besides controlled use of methadone, heroin, cannabis and benzodiazepines were the most commonly used drugs. Hepatitis C prevalence was high (29.9%) despite low antenatal screening rates (57.7%). Neonatal morbidity was related to prematurity (22.9%), small for dates (28.6%) and neonatal abstinence syndrome (NAS; 58.9%). By day 5 of life, 95.1% of the babies developing NAS and 96.1% of those requiring pharmacological treatment were symptomatic. Of the infants developing NAS, 31.7% required pharmacological treatment. A total of 82.5% babies went home with their mother, and 21.2% were placed on the Child Protection Register. Only 14.3% were breast feeding at discharge. Illicit substance use in pregnancy continues to be associated with significant maternal and neonatal morbidity, and the socio-clinical profile in this decade appears unchanged in the UK. Hepatitis C prevalence is high, and detection should be improved through targeted antenatal screening. Where facility in the community is unavailable, 5 days of hospital stay is sufficient to safely identify babies at risk of developing NAS. Most babies were discharged home with their mother. |
| | |
Authors:
|
Nitin Goel; Dana Beasley; Veena Rajkumar; Sujoy Banerjee |
Related Documents
:
|
11080468 - Why some women do not breast feed: bottle feeding and fathers' role. 17725148 - The changes of sexuality in thai women during pregnancy. 3945268 - Pregnancy during residency. 20594638 - Turner syndrome and pregnancy: clinical practice. recommendations for the management of... 1565358 - Pregnancy complicated by hereditary spherocytosis. 1352488 - Autacoids affecting vascular tone in the human fetal extracorporeal circulation. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-09 |
Journal Detail:
|
Title: European journal of pediatrics Volume: 170 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
|
Languages: eng Pagination: 199-205 Citation Subset: IM |
Affiliation:
|
Department of Neonatal Medicine, Division of Women and Child Health, ABM University Health Board, Singleton Hospital, Sketty Lane, Swansea, SA2 8QA, UK, drnitingoel@yahoo.co.in. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neonatal sepsis following maternal amnionitis by Edwardsiella tarda: a case report and a review of t...
Next Document: Critical incidents in paediatric critical care: who is at risk?