Document Detail

Perinatal outcome following suspected fetal abnormality when managed through a fetal management unit.
MedLine Citation:
PMID:  20063325     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the perinatal outcomes of the first 1057 cases seen at a fetal management unit (FMU). METHODS: Record linkage of FMU data with the Victorian Birth data and the Victorian Births Defects Register (BDR). RESULTS: Ninety-nine percent of cases were followed up with 811 (77%) linked to the BDR and 202 (22%) linked to the birth data. Almost two-thirds of cases with birth defects (528) were live births surviving 28 days, 52 (6%) were neonatal deaths, 26 (3%) were stillbirths and 205 (25%) were terminations. The birth defects most prevalent were of the heart/circulatory system (31%). Cases that resulted in a termination were significantly more likely to have multiple birth defects [OR 2.43 (95% CI 1.70, 3.48)], a chromosomal birth defect [OR 3.30 (95% CI 1.96, 5.57)], a lethal birth defect [OR 1.32 (95% CI 1.25, 1.38)], or a syndrome [OR 4.81 (95% CI 2.54, 9.11)]. In this setting, 61% of cases of Down syndrome resulted in a live birth. CONCLUSION: Over three-quarters of cases referred to the FMU were confirmed with a birth defect and notified to the BDR. Notably, two-thirds of the cases (with or without a birth defect) were live births surviving 28 days.
Sharon Lewis; George McGillivray; Shelley Rowlands; Jane Halliday
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Copyright Information:
(c) 2010 John Wiley & Sons, Ltd.
Public Health Genetics, Murdoch Childrens Research Institute, Melbourne, Australia.
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MeSH Terms
Congenital Abnormalities / mortality
Fetus / abnormalities*
Gestational Age
Infant Mortality*
Infant, Newborn
Perinatal Care*
Perinatal Mortality*
Prenatal Diagnosis / mortality*

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