Document Detail


Perinatal outcome of congenital diaphragmatic hernia in an Australian tertiary hospital.
MedLine Citation:
PMID:  22145569     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Congenital diaphragmatic hernia (CDH) is a potentially correctable anatomical defect that continues to represent a significant cause of stillbirth and neonatal death. Aims:  To describe the outcomes of fetuses diagnosed antenatally with CDH. Methods:  A retrospective cohort study of fetuses with CDH detected antenatally at our fetal medicine unit between January 1996 and December 2008. The study analyses factors associated with mortality in a setting where no fetal intervention for this condition is performed. Results:  Eighty-six cases were identified and 75.5% of infants were born alive. Mortality prior to corrective surgery was 7%. The survival rate for babies born at term with isolated CDH was 83%. Presence of an additional anomaly, herniated liver and preterm delivery were associated with increased mortality. Seventy-four percent of liveborn infants with either isolated CDH or other anomalies survived to discharge. Conclusions:  Although the overall mortality rate for this condition remains high, fetuses with isolated CDH born at term have relatively high survival rates. This study provides data for counselling parents in tertiary centres with advanced neonatal care but where antenatal intervention for this condition has not been introduced.
Authors:
Edward O'Mahony; Michael Stewart; Amanda Sampson; Christine East; Ricardo Palma-Dias
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-6
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  -     ISSN:  1479-828X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology © 2011 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Affiliation:
Fetal Medicine Unit, Department of Perinatal Medicine, Royal Women's Hospital Department of Obstetrics and Gynaecology, University of Melbourne Department of Neonatology, Royal Children's Hospital Neonatal Services Ultrasound Department, Royal Women's Hospital, Melbourne, Vic., Australia.
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