Document Detail


Perinatal outcome of ICSI pregnancies compared with a matched group of natural conception pregnancies in Flanders (Belgium): a cohort study.
MedLine Citation:
PMID:  16168226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective cohort study was conducted with an intracytoplasmic sperm injection (ICSI) group and a naturally conceived comparison group. A total of 1655 singleton and 1102 twin ICSI births were studied with regard to perinatal outcome. Control subjects (naturally conceived pregnancies) were selected from a regional registry and were matched for maternal age, parity, place of delivery, year of birth and fetal sex. The main outcome measures were duration of pregnancy, birth weight, Apgar score <5 after 5 min, neonatal complications, perinatal death and congenital malformations. Twin births, when compared with singletons, carry a much higher risk of poor perinatal outcome. For both ICSI singletons and ICSI twins, no significant difference was found between ICSI and naturally conceived pregnancies for all investigated parameters. After excluding like-sex twin pairs, ICSI twin pregnancies were at increased risk for perinatal mortality (OR = 2.74, CI = 1.26-5.98), prematurity (OR = 1.38, CI = 1.10-1.75) and low birth weight (OR = 1.34, CI = 1.06-1.69) compared with spontaneously conceived different-sex twin pairs. In conclusion, the perinatal outcome of ICSI singleton and twin pregnancies was very similar to that of spontaneously conceived pregnancies in this large cohort study. After excluding like-sex twin pairs, ICSI twins were at increased risk for prematurity, low birth weight and higher perinatal mortality compared with the natural conception comparison group.
Authors:
Willem Ombelet; Karen Peeraer; Petra De Sutter; Jan Gerris; Eugene Bosmans; Guy Martens; Gunther Ruyssinck; Paul Defoort; Geert Molenberghs; Wilfried Gyselaers
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Publication Detail:
Type:  Comparative Study; Journal Article; Twin Study    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  11     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2005-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-53     Citation Subset:  IM    
Affiliation:
Genk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, Genk, Belgium. willem.ombelet@pandora.be
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MeSH Terms
Descriptor/Qualifier:
Adult
Belgium
Cohort Studies
Female
Humans
Pregnancy
Pregnancy Outcome*
Retrospective Studies
Sperm Injections, Intracytoplasmic*

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