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Perinatal and neonatal outcomes of 494 babies delivered from 972 vitrified embryo transfers.
MedLine Citation:
PMID:  22464083     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the safety of vitrification of embryos by comparing the perinatal outcome of vitrified day 3 ETs with fresh cleavage-stage ETs. DESIGN: Retrospective analysis. SETTING: Assisted reproduction center. PATIENT(S): A total of 806 women with 494 infants delivered were included. INTERVENTION(S): Supernumerary embryos and embryos of patients at risk of ovarian hyperstimulation syndrome were vitrified using a Cryotop carrier in an open system and were transferred after warming. MAIN OUTCOME MEASURE(S): Implantation and pregnancy rates, obstetric outcomes, neonatal outcomes, and congenital birth defects. RESULT(S): A total of 2,543 vitrified embryos were warmed, and 2,375 survived and were transferred. The implantation, pregnancy, miscarriage, and live birth rates were 26.91%, 47.22%, 6.07%, and 38.58%, respectively. In singletons, the mean birth weight was 3,337.44 g, and the mean Apgar scores were 8.91, 9.85, and 9.89 at 1, 5, and 10 minutes, respectively. In multiple gestations, the mean birth weight was 2,556.45 g, and the mean Apgar scores were 8.90, 9.34, and 9.47 at 1, 5, and 10 minutes, respectively. Only seven congenital malformations were observed among the 494 babies. Compared with fresh cleavage-stage ETs, the mean birth weight in the vitrified group was higher in both singleton and multiple gestations. All the other results were similar between the two groups. CONCLUSION(S): Compared with fresh ETs, vitrified day 3 ET shows no significant differences in obstetrical and neonatal outcomes. The study suggests that vitrification with Cryotop is an effective and safe method for the cryopreservation of human cleavage-stage (day 3) embryos.
Authors:
Wenhao Shi; Xia Xue; Silin Zhang; Wanqiu Zhao; Shan Liu; Hanying Zhou; Min Wang; Juanzi Shi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Assisted Reproduction Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi'an, People's Republic of China.
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