Document Detail

Perinatal maturation of the respiratory rhythm generator in mammals: from experimental results to computational simulation.
MedLine Citation:
PMID:  16203211     Owner:  NLM     Status:  MEDLINE    
The survival of neonatal mammals requires a correct function of the respiratory rhythm generator (RRG), and therefore, the processes that control its prenatal maturation are of vital importance. In humans, lambs and rodents, foetal breathing movements (FBMs) occur early during gestation, are episodic, sensitive to bioamines, central hypoxia and inputs from CNS upper structures, and evolve with developmental age. In vitro, the foetal rodent RRG studied in preparations where the upper CNS structures are lacking continuously produces a rhythmic command, which is sensitive to hypoxia and bioaminergic inputs. The rhythm is slow with variable periods 4 days before birth. It becomes faster 2 days before birth, similar to the postnatal rhythm. Compelling evidence suggests that a region of the RRG called the preBötzinger complex (PBC) contains respiratory pacemaker neurones which play a primary role in perinatal rhythmogenesis. Although the RRG functions during early gestation, no pacemakers are found in the putative PBC area and its electrical stimulation and lesion do not affect the early foetal rhythm. To know whether the early foetal and perinatal rhythms originate from either pacemaker neurones or network connection properties, and to know which maturational processes might explain the appearance of PBC pacemakers and the rhythm increase during perinatal development, we computationally modelled maturing RRG. Our model shows that both network noise and persistent sodium conductance are crucial for rhythmogenesis and that a slight increase in the persistent sodium conductance can solve the pacemaker versus network dilemma in a noisy network.
Pablo Achard; Sébastien Zanella; Roger Rodriguez; Gérard Hilaire
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  149     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2005-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-27     Citation Subset:  IM    
CNRS UMR 6207, Centre de Physique Théorique, Case 907, 13288 Marseille cedex 9, France.
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MeSH Terms
Animals, Newborn
Computer Simulation*
Infant, Newborn
Respiratory Center / embryology*,  growth & development*
Respiratory Physiological Phenomena*

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