Document Detail


Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers.
MedLine Citation:
PMID:  22997227     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Previous studies indicated that the intake of α-linolenic acid (ALA) can alter the concentration of both ω-6 and ω-3 fatty acids in both mother and offspring, with consequences on postnatal brain development. This study describes the association between maternal ALA availability during gestation and lactation, and alterations in the Fads2 DNA methylation in both maternal and offspring livers, at the end of lactation period. Both Fads2 promoter and intron 1 DNA methylation were increased in the groups receiving postnatal flaxseed oil containing 50% ALA (mothers or pups), while bivariate analysis indicated a significant association of the Fads2 epigenetic status in the liver between each mother and its offspring. In addition, Fads2 expression was negatively correlated with promoter methylation at the individual level in maternal livers (P<0.05). This study also indicated that the interplay between ALA availability during gestation and lactation can differentially alter the expression of desaturases and elongases involved in ω-6 and ω-3 metabolic pathways. In summary, when considering the perinatal dietary ALA requirements in mice, both gestation and lactation periods should be considered as having distinct roles in modulating the metabolism of ω-6 and ω-3 fatty acids in maternal mouse livers.-Niculescu, M. D., Lupu, D. S., Craciunescu, C. N. Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers.
Authors:
Mihai D Niculescu; Daniel S Lupu; Corneliu N Craciunescu
Related Documents :
23988487 - Bile acid receptors in non-alcoholic fatty liver disease.
11123467 - Effect of various environmental parameters on the recovery of sublethally salt-damaged ...
17576057 - Enhanced enteric properties and stability of shellac films through composite salts form...
24550457 - Evolutionary history and metabolic insights of ancient mammalian uricases.
12723837 - The effect of acid primer or conventional acid etching on microleakage in a photoactiva...
17645207 - Processing of fresh palm fruits using microwaves.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  -     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina, USA; and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.
Next Document:  Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting v...