| Perinatal magnetic resonance fetal lung volumetry and fetal lung-to-liver signal intensity ratio for predicting short outcome in isolated congenital diaphragmatic hernia and cystic adenomatoid malformation of the lung. | |
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MedLine Citation:
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PMID: 18412776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the usefulness of magnetic resonance imaging (MRI) in predicting the risk of lethal pulmonary hypoplasia in fetuses. METHODS: The subjects consisted of 15 fetuses (29-40 weeks' gestation), including fetuses with major malformation diagnosed on prenatal ultrasonography. MRI using a 1.5 T magnet and half-Fourier acquisition single-shot fast spin-echo sequences were applied to all fetuses at 29-36 weeks. Fetal lung-to-liver signal intensity ratio (LLSIR) was calculated by medians of region-of-interest analysis; estimated fetal bodyweight (FBW), by ultrasonography; and estimated fetal lung volume (FLV), by planimetric measurement of total lung volume. FLV/FBW was also calculated. The presence of the pulmonary hypoplasia in neonates was identified based on clinical and anatomico-pathological findings. Differences in LLSIR and FLV/FBW were analyzed for surviving and non-surviving neonates. RESULTS: Ten surviving neonates had a median LLSIR of 3.00, range: 1.60-4.40, while that in seven non-surviving neonates was 2.21, range: 0.70-3.72; no significant difference was found between the groups. Surviving neonates had a median FLV/FBW of 11.4, range: 7.1-15.7, while that in non-surviving neonates was 4.4, range: 3.1-5.7. FLV/FBW in non-surviving neonates was significantly lower than that of the FLV/FBW for surviving fetuses (P<0.05). CONCLUSIONS: Low FLV/FBW may be useful in prenatally predicting mortality in fetuses with pulmonary hypoplasia. |
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Authors:
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Mitsuru Matsushita; Keisuke Ishii; Masaki Tamura; Yasuhiro Takahashi; Takeshi Kamura; Koichi Takakuwa; Kenichi Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 34 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-16 Completed Date: 2008-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Japan |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. bachi1970@sis.seirei.or.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cystic Adenomatoid Malformation of Lung, Congenital
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diagnosis* Female Fetus Hernia, Diaphragmatic / congenital, diagnosis* Humans Infant, Newborn Lung Volume Measurements / methods* Magnetic Resonance Imaging / methods* Perinatal Care / methods Pregnancy Retrospective Studies |
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