Document Detail

Perinatal infection of human T-lymphotropic virus type I, the etiologic virus of adult T-cell leukemia/lymphoma. DNA amplification of specific human T-lymphotropic virus type I sequences.
MedLine Citation:
PMID:  2224789     Owner:  NLM     Status:  MEDLINE    
A gene amplification technique, polymerase chain reaction, was used to detect human T-lymphotropic virus type I (HTLV-I), the etiologic agent of adult T-cell leukemia/lymphoma, in mononuclear cells in peripheral blood and breast milk of ten HTLV-I carrier gravida. The DNA in umbilical cord blood mononuclear cells of the neonates born to the HTLV-I carrier gravida were also amplified and examined for the possibility of HTLV-I infection via placenta during pregnancy. The HTLV-I sequences were detected both in the peripheral blood and milk of all ten carrier gravida by Southern blot analysis of amplified DNA. However, HTLV-I proviral DNA could not be detected in the cord blood of the carriers' neonates, indicating that transplacental infection of HTLV-I should be rare and that postpartum infection via breast milk is a likely major perinatal transmission route.
F Saji; K Ohashi; Y Tokugawa; S Kamiura; C Azuma; O Tanizawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  66     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1933-7     Citation Subset:  AIM; IM; X    
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
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MeSH Terms
Antibodies, Neoplasm / immunology
Antigens, Neoplasm / immunology
Base Sequence
Blotting, Southern
Breast Feeding
Fetal Blood / microbiology
Gene Amplification*
HTLV-I Infections / blood,  transmission
Human T-lymphotropic virus 1 / physiology*
Infant, Newborn
Leukemia-Lymphoma, Adult T-Cell / etiology,  microbiology*
Leukocytes, Mononuclear / physiology
Milk, Human / microbiology
Molecular Sequence Data
Pregnancy Complications, Infectious / etiology,  microbiology*
Reg. No./Substance:
0/Antibodies, Neoplasm; 0/Antigens, Neoplasm

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