Document Detail

Perinatal and infant mortality and low birth weight among residents near cokeworks in Great Britain.
MedLine Citation:
PMID:  10735516     Owner:  NLM     Status:  MEDLINE    
With growing evidence of the adverse health effects of air pollution--especially fine particulates--investigators must concentrate on the fetus, neonate, and infant as potentially vulnerable groups. Cokeworks are a major source of smoke and sulfur dioxide. In the current study, the authors investigated whether populations residing near cokeworks had a higher risk of adverse perinatal and infant outcomes. Zones of 7.5-km radius around 22 cokeworks in Great Britain were studied, within which the authors assumed that exposure declined from highest levels within 2 km to background levels. Routinely recorded birth and death data for Great Britain during the period 1981-1992 were analyzed. Each individual record had a postcode that referred to a small geographical area of typically 15-17 addresses. The authors calculated expected numbers on the basis of regional rates, stratified by year, sex, and a small-area socioeconomic deprivation score. For all cokeworks combined, the observed/expected ratio (95% confidence intervals within parentheses) within 2 km of cokeworks was 1.00 (0.95, 1.06) for low-birth-weight (i.e., < 2,500 g) infants; 0.94 (0.78, 1.12) for still births; 0.95 (0.83, 1.09) for infant mortality; 0.86 (0.72, 1.03) for neonatal mortality; 1.10 (0.90, 1.33) for postneonatal mortality; 0.79 (0.30, 1.46) for respiratory postneonatal mortality; and 1.07 (0.77, 1.43) for postneonatal Sudden Infant Death Syndrome. Respiratory postneonatal mortality was low throughout the entire 0-7.5-km study area (observed/expected = 0.74 [0.61, 0.88]). There was no statistically significant decline in risk with distance from cokeworks for any of the outcomes studied. The authors concluded that there was no evidence of an increased risk of low birth weight, stillbirths, and/or neonatal mortality near cokeworks, and there was no strong evidence for any association between residence near cokeworks and postneonatal mortality. One must remember, however, the limited statistical power of the study to detect small risks.
H Dolk; S Pattenden; M Vrijheid; B Thakrar; B Armstrong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental health     Volume:  55     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-04-12     Completed Date:  2000-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  AIM; IM    
Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, UK.
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MeSH Terms
Air Pollutants / adverse effects*
Databases, Factual
Great Britain / epidemiology
Infant Mortality*
Infant, Low Birth Weight*
Infant, Newborn
Sudden Infant Death / epidemiology
Reg. No./Substance:
0/Air Pollutants; 0/Coal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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