| Perinatal hypoxic-ischemic thalamic injury: clinical features and neuroimaging. | |
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MedLine Citation:
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PMID: 9708537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A common pattern of hypoxic-ischemic cerebral injury in the term newborn involves predominantly cerebral cortex and subcortical white matter. We describe 20 term newborns with moderate or severe acute hypoxic-ischemic encephalopathy who exhibit a different pattern of abnormalities on computed tomography, with evidence of decreased tissue attenuation predominantly in thalami and basal ganglia and relative preservation of cerebral cortex and white matter. Profound, acute hypoxic-ischemic insult (eg, umbilical cord prolapse, uterine rupture, or massive placental abruption) was documented in 16 of 20 infants (80%). Characteristic clinical features during the newborn period included irritability, tonic posturing of limbs, and persistent lower cranial nerve dysfunction, often with prominent tongue fasciculations. This pattern of central injury appears to be highly predictive of poor outcome; 7 newborns (35%) died, and all survivors who had follow-up to 18 months of age (11) had major neurological sequelae (eg, spastic quadriplegia, choreoathetosis, and persistent feeding problems). This pattern of hypoxic-ischemic cerebral injury corresponds closely to experimental animal models of "acute total" perinatal asphyxia. |
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Authors:
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E H Roland; K Poskitt; E Rodriguez; B A Lupton; A Hill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 44 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-25 Completed Date: 1998-08-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Division of Neurology, University of British Columbia, British Columbia's Children's Hospital, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apgar Score Basal Ganglia / radiography Brain Damage, Chronic / congenital*, diagnosis*, mortality, therapy Diagnostic Techniques, Neurological Female Fetal Hypoxia / complications* Follow-Up Studies Humans Infant, Newborn Ischemic Attack, Transient / complications, diagnosis*, mortality Magnetic Resonance Imaging Observer Variation Predictive Value of Tests Pregnancy Pregnancy Outcome Putamen / pathology Survival Rate Thalamic Diseases / congenital*, diagnosis*, mortality Thalamus / pathology, radiography Tomography, X-Ray Computed* |
| Comments/Corrections | |
Comment In:
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Ann Neurol. 1998 Aug;44(2):155-6
[PMID:
9708534
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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