Document Detail

Perinatal hypoxic-ischaemic brain injury: prediction of outcome.
MedLine Citation:
PMID:  8224563     Owner:  NLM     Status:  MEDLINE    
Twenty-six term babies with hypoxic-ischaemic brain injury were studied during the neonatal period to evaluate the prediction of outcome to at least one year of age by means of ultrasonography, CT scanning and Doppler ultrasound assessment of cerebral palsy blood flow velocity (CBFV). Adverse outcome was defined as the occurrence of cerebral palsy, developmental delay or death. At follow-up, 17 infants had an adverse outcome (seven died, 10 had disability); the remainder had no detectable impairment. Abnormalities on cranial ultrasound were not, but generalised decreased tissue density on CT scan was, associated with adverse outcome. Abnormal mean CBFV in the middle cerebral artery had no association with outcome, but abnormal mean CBFV in the anterior cerebral artery and a low resistance index in both arteries were significantly associated with adverse outcome. Such information may be used for appropriate counselling of parents of asphyxiated infants.
P H Gray; D I Tudehope; J P Masel; Y R Burns; H A Mohay; M J O'Callaghan; G M Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  35     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-02     Completed Date:  1993-12-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  965-73     Citation Subset:  IM    
Mater Mothers' Hospital, South Brisbane QLD, Australia.
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MeSH Terms
Asphyxia Neonatorum / complications*,  physiopathology
Blood Flow Velocity
Brain / radiography
Brain Ischemia / diagnosis*
Cerebrovascular Circulation
Hypoxia, Brain / diagnosis*
Infant, Newborn
Prospective Studies
Tomography, X-Ray Computed

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