Document Detail

Perinatal hypoxia induces subsequent retinal degeneration in the offspring of ovoviviparous fish, Xiphophorous maculates.
MedLine Citation:
PMID:  17760707     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This experiment evaluated the perinatal hypoxic effect on the retina of offspring of the ovoviviparous fish. ANIMAL STUDIED: The ovoviviparous fish Xiphophorous maculates was used for the experiment. PROCEDURE: The mothers were kept in a hypoxic environment of 3.5% oxygen for 6 h, starting 30 h before hatching. Subsequently, the retinae of the offspring were fixed, sectioned at 6 microm and evaluated microscopically from the age of 1 to 35 days. RESULTS: Degeneration of the outer nuclear layer of the retina was noted on the 3rd day and severe retinal degeneration was observed on the 35th day. Immunocytochemistry confirmed apoptosis by TUNEL reaction. There was no difference in neovascularization, as revealed by vascular endothelial growth factor, between controls (group 1) and hypoxic fish (group 2). CONCLUSIONS: Perinatal hypoxia could have long-lasting effects on the central nervous system in some species.
Lan-Hai Lü; Ji-Cheng Li; Maria Sen Mun Wai; Wai Ping Lam; E Lucy Forster; Ma-Rong Fang; David T Yew
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  10     ISSN:  1463-5216     ISO Abbreviation:  Vet Ophthalmol     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Institute of Cell Biology, Medical School of Zhejiang University, Hangzhou, China.
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MeSH Terms
Anoxia / complications,  veterinary*
Fish Diseases / etiology*,  pathology
In Situ Nick-End Labeling / veterinary
Random Allocation
Retinal Degeneration / etiology,  pathology,  veterinary*
Retinal Neovascularization / veterinary
Species Specificity
Vascular Endothelial Growth Factors / metabolism
Reg. No./Substance:
0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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