Document Detail

Perinatal group B streptococcal disease.
MedLine Citation:
PMID:  17336588     Owner:  NLM     Status:  MEDLINE    
Group B streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis. Despite optimal treatment of GBS-infected neonates it is associated with significant morbidity and mortality, and prevention strategies are required. As disease occurs rapidly, and is often evident at birth or within 12 hours of birth, antibiotics must be given prior to delivery, and when administered early enough, and at the correct doses, they will prevent the majority of early-onset GBS cases. Prevention is therefore in the hands of obstetricians and midwives. Women at higher risk of delivering infected infants can be identified through one of two strategies: the presence of one or more clinical risk factors, or the presence of GBS on lower vaginal/rectal swabs obtained late in pregnancy. Decisions on which strategy to use will depend on a number of factors. A swab-based approach appears to have higher efficacy but is likely to lead to more antibiotic exposure.
Paul T Heath; Anne Schuchat
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-03-02
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  21     ISSN:  1521-6934     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-24     Citation Subset:  IM    
Vaccine Institute and Division of Child Health, St George's, University of London, London SW17 0RE, UK. <>
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Infant, Newborn
Perinatal Care*
Pregnancy Complications, Infectious / diagnosis,  epidemiology,  prevention & control*
Prenatal Diagnosis
Streptococcal Infections / diagnosis,  epidemiology,  prevention & control*
Streptococcus agalactiae*
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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