Document Detail

Perinatal echovirus infection: insights from a literature review of 61 cases of serious infection and 16 outbreaks in nurseries.
MedLine Citation:
PMID:  3541126     Owner:  NLM     Status:  MEDLINE    
A review of literature published before June 1985 revealed 61 reported cases of neonatal echovirus infection at a nonmucosal site, including 43 cases (70%) due to echovirus 11. Onset of disease occurred between the third and fifth days of life in 63% of cases, indicating that most infections are acquired in the immediate perinatal period rather than in utero. Mortality was higher in infants with severe hepatitis (83%) than in infants with infection of the central nervous system (19%). Acute illness occurred within one week before delivery in 68% of the mothers of nonnosocomially infected infants. There was a trend (P = .11) towards a higher mortality rate for infants born by cesarian section than for those delivered vaginally. In the 11 nosocomially acquired cases, the onset of infection was later and the mortality rate lower. In 16 outbreaks in nurseries, 206 infants developed illness attributed to echovirus infection. Attack rates of clinical disease were 22%-52% and illness was generally mild. In four outbreaks, six index cases were identified as infants who had acquired infection from their mothers; five of these infants had severe disease and three died. The 24 infants subsequently infected by nosocomial spread in these outbreaks had milder disease; three (12%) died. Thus, whereas acute illness in the mother before birth often precedes neonatal echovirus infection and infections transmitted vertically from mother to infant may be severe, postnatal transmission of the same serotype results in milder disease.
J F Modlin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  8     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1987-02-06     Completed Date:  1987-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-26     Citation Subset:  IM    
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MeSH Terms
Cross Infection*
Echovirus Infections* / epidemiology,  transmission
Hepatitis, Viral, Human*
Infant, Newborn
Meningitis, Viral*
Pregnancy Complications, Infectious

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