Document Detail

Perinatal diagnosis of passive ITP: use of percutaneous umbilical blood sampling (PUBS).
MedLine Citation:
PMID:  2752169     Owner:  NLM     Status:  MEDLINE    
Fetal blood samples can be obtained in utero by direct sampling of the umbilical cord vessels, using an ultrasound guided technique termed percutaneous umbilical sampling (PUBS). This procedure is being used more frequently in high risk pregnancies to obtain direct fetal laboratory data. In specialized centers, with trained personnel, the technique can be used with a high degree of safety and efficiency. Direct access to the fetal circulation can also allow an accurate determination of the fetal platelet count in cases of suspected fetal thrombocytopenia. The technique may be used to plan appropriate clinical management of maternal ITP as well as to diagnose the presence of fetal alloimmune thrombocytopenia. A logical strategy for obstetric management and evaluation of fetal risk can be planned. The procedure also has the potential to allow direct fetal treatment as has been the case in the management of severe fetal anemia.
R A Sacher; J C King
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blut     Volume:  59     ISSN:  0006-5242     ISO Abbreviation:  Blut     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-29     Completed Date:  1989-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173401     Medline TA:  Blut     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  128-31     Citation Subset:  IM    
Department of Laboratory Medicine, Georgetown University Medical Center, Washington.
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MeSH Terms
Autoimmune Diseases / diagnosis*
Fetal Blood
Fetal Diseases / diagnosis*,  therapy
Immunization, Passive
Infant, Newborn
Infant, Newborn, Diseases / diagnosis*
Purpura, Thrombocytopenic / diagnosis*

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