Document Detail


Perinatal cytomegalovirus hepatitis: to treat or not to treat with ganciclovir.
MedLine Citation:
PMID:  15265185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The use on ganciclovir for perinatal cytomegalovirus (CMV) infection is controversial. We aim to evaluate the use of ganciclovir treatment for neonatal CMV hepatitis. METHODS: We present five infants with perinatally-acquired CMV hepatitis as a single organ manifestation of CMV infection. The three more severely affected children, i.e. those with cholestasis and elevation of serum hepatic enzymes to more than twice the normal values, were treated for 15 days with intravenous ganciclovir. RESULTS: The three treated infants improved clinically and CMV DNA in the blood disappeared during treatment. After cessation of ganciclovir treatment all of the patients had a relapse of the infection. The two untreated patients recovered completely. CONCLUSION: The long-term outcome of infants with CMV hepatitis is unpredictable. Some patients have persistent liver injury despite ganciclovir therapy. Ganciclovir therapy did not prevent chronic liver disease in any of the patients in our study. Owing to the possible serious side-effects the cost-benefit of ganciclovir treatment should be carefully evaluated.
Authors:
Z Vancíková; T Kucerová; L Pelikán; L Zikmundová; M Priglová
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  40     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-21     Completed Date:  2004-12-02     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  444-8     Citation Subset:  IM    
Affiliation:
First Department of Paediatrics, University Hospital Motol, Prague, Czech Republic. vancikova@email.cz
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Antiviral Agents / therapeutic use*
Aspartate Aminotransferases / blood
Cytomegalovirus / drug effects
Cytomegalovirus Infections / drug therapy*
Ganciclovir / therapeutic use*
Hepatitis, Viral, Human / drug therapy*
Humans
Infant
Liver / drug effects,  metabolism,  pathology
Perinatal Care
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiviral Agents; 82410-32-0/Ganciclovir; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

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