| Perinatal corticosteroids and the developing lung. | |
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MedLine Citation:
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PMID: 12065185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A significant number of infants are born prematurely each year, many of whom will develop respiratory disease and require ventilation. A substantial number of these infants will die and many of the survivors will subsequently develop chronic inflammatory lung disease. Administration of corticosteroids to women prior to a premature delivery is associated with a significant reduction in mortality and in the incidence of respiratory distress syndrome and intracranial haemorrhage in their infants once born. Postnatal administration of corticosteroids to the infant who develops chronic lung disease has been widely practised for many years. Recent meta-analyses have suggested that benefit may be limited. Treatment is also associated with a range of different side-effects but it has been assumed that the cost-benefit ratio favoured treatment. Recent evidence of permanent and highly significant long-term adverse effects has questioned the validity of this judgement. |
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Authors:
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Alan T Gibson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Paediatric respiratory reviews Volume: 3 ISSN: 1526-0542 ISO Abbreviation: Paediatr Respir Rev Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-06-14 Completed Date: 2002-07-18 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 100898941 Medline TA: Paediatr Respir Rev Country: England |
Other Details:
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Languages: eng Pagination: 70-6 Citation Subset: IM |
Affiliation:
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North Trent Neonatal Intensive Care Unit, Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Tree Root Walk, Sheffield S10 2SF, UK. A.T.Gibson@Sheffield.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage* Female Humans Infant, Newborn Infant, Premature / growth & development* Lung / drug effects*, growth & development* Neonatology / methods Perinatal Care / methods Pregnancy Respiratory Distress Syndrome, Newborn / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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