| Perinatal collagen turnover markers in intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 22339296 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To investigate bone and connective tissue collagen turnover in intrauterine-growth-restricted-(IUGR) pregnancies, by determining circulating markers of type I collagen synthesis (carboxy-terminal propeptide of type I procollagen [PICP], representing bone formation) and degradation (cross-linked telopeptide of type I collagen [ICTP], representing bone resorption), as well as type III collagen synthesis (N-terminal propeptide of type-III procollagen [PIIINP], reflecting growth and tissue maturity). Methods: Plasma PICP, ICTP and PIIINP concentrations were measured in 40 mothers and their 20 asymmetric IUGR and 20 appropriate-for-gestational-age-(AGA) full-term fetuses and neonates on postnatal day 1-(N1) and 4-(N4). Results: Fetal PICP, fetal and N4 ICTP, as well as fetal, N1 and N4 PIIINP concentrations were higher in the IUGR group (p≤0.038, in all cases). In both groups, maternal PICP, ICTP and PIIINP concentrations were lower than fetal, N1 and N4 ones (p<0.001, in each case). Conclusions: Type I collagen turnover is enhanced in IUGR than AGA fetuses/neonates. Similarly, fetal/neonatal PIIINP concentrations are elevated in IUGR, probably due to stress, responsible for induction of tissue maturation, and/or to impaired excretory renal function, leading to reduced protein clearance. Fetal/neonatal PICP, ICTP and PIIINP concentrations are higher than maternal ones, possibly reflecting increased skeletal growth and collagen turnover in the former. |
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Authors:
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Demetrios Gourgiotis; Despina D Briana; Anestis Georgiadis; Maria Boutsikou; Stavroula Baka; Antonios Marmarinos; Demetrios Hassiakos; Ariadne Malamitsi-Puchner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-17 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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