| Perinatal cisplatin exposure induces cochlear apoptosis in newborn guinea pigs. | |
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MedLine Citation:
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PMID: 20396870 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for seven consecutive days at gestational day (GD) 51 to GD 57. At postnatal day (PND) 14, pups were examined in the distortion product otoacoustic emission (DPOAE) task. The temporal bones were then removed and immunohistochemically stained for caspase 3, using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) method. Cisplatin used during pregnancy could induce hearing loss in newborn and cochlear hair cell apoptosis. In conclusion, apoptosis may play an important role in the development of hearing impairment, caused by perinatal cisplatin exposure. |
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Authors:
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Shuai Hao; Xuejun Jiang; Aihui Yan; Bo Yang |
Publication Detail:
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Type: Journal Article Date: 2010-04-16 |
Journal Detail:
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Title: Archives of toxicology Volume: 85 ISSN: 1432-0738 ISO Abbreviation: Arch. Toxicol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: Germany |
Other Details:
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Languages: eng Pagination: 19-25 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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