Document Detail


Perinatal brain damage causation.
MedLine Citation:
PMID:  17762196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The search for causes of perinatal brain damage needs a solid theoretical foundation. Current theory apparently does not offer a unanimously accepted view of what constitutes a cause, and how it can be identified. We discuss nine potential theoretical misconceptions: (1) too narrow a view of what is a cause (causal production vs. facilitation), (2) extrapolating from possibility to fact (potential vs. factual causation), (3) if X, then invariably Y (determinism vs. probabilism), (4) co-occurrence in individuals vs. association in populations, (5) one cause is all that is needed (single cause attribution vs. multicausal constellations), (6) drawing causal inferences from very small numbers of observations (the tendency to generalize), (7) unstated causal inferences, (8) ignoring heterogeneity, and (9) failing to consider alternative explanations for what is observed. We hope that our critical discussion will contribute to fruitful research and help reduce the burden of perinatal brain damage.
Authors:
Olaf Dammann; Alan Leviton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental neuroscience     Volume:  29     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-05     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  280-8     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Affiliation:
Perinatal Infectious Disease Epidemiology Unit, OE 6415, Hannover Medical School, Hannover, Germany. ODammann@tufts-nemc.org
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MeSH Terms
Descriptor/Qualifier:
Abruptio Placentae / epidemiology,  physiopathology
Birth Injuries / epidemiology*,  physiopathology
Causality
Cerebral Hemorrhage, Traumatic / epidemiology,  physiopathology
Female
Humans
Hypoxia, Brain / epidemiology*,  physiopathology
Infant, Newborn
Leukomalacia, Periventricular / epidemiology,  physiopathology
Pregnancy
Grant Support
ID/Acronym/Agency:
NS040069/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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