| Perinatal asphyxia, hyperthermia and hyperferremia as factors inducing behavioural disturbances in adulthood: a rat model. | |
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MedLine Citation:
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PMID: 16038989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alertness was studied in adult male Wistar rats after neonatal critical anoxia applied under three different thermal conditions: (i) at physiological neonatal body temperature of 33 degrees C, (ii) at body temperature elevated to 37 degrees C, and (iii) at body temperature elevated to 39 degrees C (both during anoxia and for 2 h postanoxia). To elucidate the effect of iron-dependent postanoxic oxidative damage to the brain, half of the group (iii) was injected with deferoxamine, a chelator of iron. Postanoxic behavioural disturbances were recorded in open-field, elevated plus-maze, and sudden silence tests when the rats reached the age of 4 month. Moreover, spontaneous motor activity of the rats was recorded radiotelemetrically in their home-cages. Both open-field stress-induced and spontaneous motor activity were reduced in rats subjected to neonatal anoxia under hyperthermic conditions. In contrast, these rats were hyperactive in the plus-maze test. Both the plus-maze and sudden silence tests revealed that these rats show reduced alertness to external stimuli signalling potential dangers. The behavioural disturbances were prevented by the body temperature of 33 degrees C and by postanoxic administration of deferoxamine. These data support the conclusion that permanent postanoxic behavioural disturbances are due to iron-dependent oxidative damage to the brain, which can be prevented by the reduced neonatal body temperature. |
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Authors:
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Michał Caputa; Justyna Rogalska; Katarzyna Wentowska; Anna Nowakowska |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioural brain research Volume: 163 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 246-56 Citation Subset: IM |
Affiliation:
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Department of Animal Physiology, Institute of General and Molecular Biology, N. Copernicus University, Toruń, Poland. caputa@biol.uni.torun.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Anoxia / etiology Asphyxia / complications* Attention Deficit and Disruptive Behavior Disorders / etiology* Behavior, Animal / physiology* Body Temperature / drug effects, physiology Deferoxamine / toxicity* Disease Models, Animal Exploratory Behavior / drug effects, physiology Female Fever / complications* Iron Chelating Agents / toxicity* Male Maze Learning / drug effects, physiology Motor Activity / drug effects, physiology Rats Rats, Wistar Reaction Time / drug effects, physiology Telemetry / methods |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents; 70-51-9/Deferoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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